Lena Waithe was born on 17 May 1984 in Chicago, Illinois, United States, Her parents divorced when she was three years old, and her father passed away when she was fourteen years old.

Lena Waithe identifies herself as a lesbian. She has started her relationship with Alana Mayo in 2015. They engaged in 2017 on Thanksgiving day in Tokyo.

Lena Waithe completed her primary schooling at Turner-Drew Elementary Language Academy and Chute Middle School. She then attended Evanston Township High School and graduated with a Cinema and Television Arts degree in 2006 from Columbia College Chicago.

After graduating from Columbia College in Chicago, Lena Waithe has acted as well as wrote the script for different television series. In 2012, she wrote the script for two other series, ‘M.O Diaries,’ and ‘How To Rock’ for two episodes. Lena Waithe landed her first acting role in the 2018 film ‘Ready Player One’ as Helen. Before this, she used to direct, produce, and write the script of the films.

she wrote the script for the drama series ‘The Chil’ in 2018, which lasted till 2020. Her other creation was ‘Boomerang,’ for which she also became an executive producer. Moreover, her latest series is ‘Twenties’ for which she is a creator and an executive producer.