Wyatt was born March 10, 1982, in Indianapolis, Indiana to Lorna Wyatt, a vocalist and Keever Wyatt II, an organist and also a vocalist. Ke'Tara "Keke" Wyatt was raised in a musical family rooted in gospel music. She has four brothers. 

Wyatt grew up in Indianapolis, but also spent time in both Kentucky and Texas. She attended high school in Indianapolis, where she was a member of her high school's varsity wrestling team. As she grew, her musical tastes were influenced by the likes of R&B greats like Stevie Wonder, Donny Hathaway and Ella Fitzgerald.

Wyatt's professional career began at the age of 10, when she began recording a song, called "What If", which would be included on a gospel compilation album for Indianapolis-based R.H. Duncan. With growing buzz surrounding "the little girl who could sing", news of Wyatt's talent lead her to encounter with these artists from the likes of Bill Woodson, Nathan Alexander, Billy Badd, Chris Kelly, and multi-platinum producer, composer Jorge Corante and Emmanuel Officer.

During the years of adolescence, Wyatt became as a student of a school by the Chicago-based producer and songwriter Steve "Stone" Huff. Huff eventually produced and shopped a few of Wyatt's demos in hopes of landing her a record deal. During her mid-teens, she performed demo songs for various gospel labels, earning around $1,500 per recording. During that time, Keke extended her skills by also writing music as a teenager, and while she was writing some music, Keke would experience her first coldly dealt disappointment as a music industry professional. She wrote the majority of the lyrics for a hit song but received no credit for her work.

Keke Wyatt is an American R&B singer and reality televisions star who has a net worth of $4 million. Keke Wyatt has released five albums since debuting with 2001's "Soul Sista" and was nominated for a 2002 Soul Train Lady of Soul Award in the Best R&B/Soul/Rap new artist category. Keke Wyatt was born on March 10, 1982 in Indianapolis, Indiana which is also where she recorded her first song "What If" when she was just 10 years old.

Throughout her career Keke has recorded several duets with fellow R&B singer Avant, including songs which helped her first album go platinum. Keke Wyatt is one of the cast member's of TV One's new reality show R&B divas. The show follows the lives of female singers Faith Evans, Monifah, Syleena Johnson, Nicci Gilbert and of course Keke.